Comparative genomic hybridization analysis of yersinia. It causes usually mild, selflimited illnesses of mesenteric adenitis, ileitis, and diarrhea but can produce serious sepsis and abscesses in immunocompromised hosts. V 57 212 7 3775 371 mesenteric caseous lymphadenitis in a cow calf caused by corynebacterium pseudotuberculosis. Corynebacterium pseudotuberculosis infection is a contagious, zoonotic disease caused by gram positive bacteria corynebacterium pseudotuberculosis old name corynebacterium ovis the infection mostly spreads from domestic grazing animals such. Use of porine from yersinia pseudotuberculosis outer coat for. Porinebased enzyme immunoassay permits the detection of antibodies to all serological variants ofy. Yersinia pseudotuberculosis is the least common of the 3 main yersinia species that cause infections in humans.
Yersinia pseudotuberculosis infectious disease and. Epizootics of pseudotuberculosis are commonly seen in birds and rodents, often with high casefatality rates. The epizootiology, epidemiology, and pathogenesis of pseudotuberculosis have not been adequately studied. First isolated in 1883, y pseudotuberculosis is a gramnegative bacterium that belongs to the genus yersinia in the enterobacteriaceae family. Pseudotuberculosis a group of insufficiently studied infectious diseases of animals and man characterized by the. Corynebacterium kutscheri causes pseudotuberculosis in mice. Diagnosis is confirmed by isolation of the bacteria from lesions. Y pseudotuberculosis primarily causes zoonotic infection in various hosts, including domestic and sylvatic animals and birds, but has been associated with foodborne infection in humans. Corynebacterium pseudotuberculosis infection of horses and.
Yersinia pseudotuberculosis adhesins regulate tissuespecific colonization and immune cell localization in a mouse model of systemic infection. Once established, this disease is difficult to eradicate because drug therapy is not effective and because the clinical detection of infected animals is of limited efficiency. Yersinia pseudotuberculosis, a gramnegative aerobic or facultative anaerobic rodshaped bacterium in the family enterobacteriaceae, is a significant and wellknown cause of disease in numerous species of domestic and wild mammals and birds, 10,26,32 and is also a recognized zoonotic foodborne pathogen. It is caused by the bacterium mycobacterium avium subspecies paratuberculosis. Infection acorynebacterium pseudotuberculosis et lymphadenite taloa ou mala chez le che chameau. In this study, the prevalence of yersinia pseudotuberculosis in wild boars in northeast germany was. Pdf recent years have witnessed the development and clinical implementation of the. Corynebacterium pseudotuberculosis infection dovemed. Corynebacterium pseudotuberculosis is the causative agent of pseudotuberculosis in sheep and of ulcerative lymphangitis in horses. Health, general economia aspectos economicos aspectos sociales epidemiology. Yersinia pseudotuberculosis has a number of virulence factors that contribute to the pathogenicity of the organism.
Yersinia pseudotuberculosis prevalence and diversity in wild boars. The virulence factors of yersinia pseudotuberculosis are positively correlated with temperature. The organism survives in environment for several months and causes disease in horses and cattle. Yersinia pseudotuberculosis is a rare cause of acute enteric disease with symptoms such as acute mesenteric lymphadenitis and gastroenteritis associated with abdominal pain and fever diarrhea is unusual. Y pseudotuberculosis primarily causes zoonotic infection in various hosts, including domestic and sylvatic animals and birds, but has been associated with foodborne infection in. Corynebacterium pseudotuberculosis is a species of the corynebacterium genus. Pseudotuberculosis, any of various diseases not caused by the tubercle bacillus but marked by the formation of tuberclelike nodules. Yersinia enterocolitica and yersinia pseudotuberculosis are. It can be associated with postinfectious complications such as erythema nodosum and reactive arthritis, and strains of y pseudotuberculosis found in asia appear to. Yersinia enterocolitica o8 from freeliving small rodents in japan. Because of the chronic and often subclinical nature of the infection, it has proved difficult to control and prevalence is high in many parts of the world, which in turn. Biotypes isolated from small ruminants and camelids are nitrate negative, while.
Enterobacteriaceae yersinieae yersinia pseudotuberculosis. The agent is typically identified in the western united states but has recently been identified in canada. Corynebacterium pseudotuberculosis and its role in ovine. Feb 11, 2016 yersinia pseudotuberculosis has a number of virulence factors that contribute to the pathogenicity of the organism. Yersinia pseudotuberculosis septicemia and hiv cdc. Infections normally affect ruminants mammals that have four compartments of their stomachs, of which the rumen is one, but have also. Corynebacterium pseudotuberculosis wikivet english. Yersinia pseudotuberculosis, a gramnegative zoonotic bacterial pathogen, causes acute gastroenteritis and mesenteric lymphadenitis, which are often accompanied by fever and abdominal pain. Corynebacterium pseudotuberculosis is a rod shaped, gram positive and aerobic bacteria.
Infeccion por corynebacterium pseudotuberculosis y linfadenitis taloa o. Pseudotuberculosis, an infection caused by the ubiquitous enteropathogenic bacterium yersinia pseudotuberculosis, is a recurrent veterinary problem in livestock and zoo animals. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Start studying enterobacteriaceae yersinieae yersinia pseudotuberculosis. Yersinia pseudotuberculosis an overview sciencedirect.
Theres a laboratory test which can check for the disease. Yersinia pseudotuberculosis is a gramnegative enteropathogen, which infects cells of the gut wall via binding to. Positive cultures to corynebacterium pseudotuberculosis were only obtained from lesions in adult animals. Yersinia pseudotuberculosis article about yersinia. Yersinia pseudotuberculosis synonyms, yersinia pseudotuberculosis pronunciation, yersinia pseudotuberculosis translation, english dictionary definition of yersinia pseudotuberculosis. Yersinia pseudotuberculosis is a coldtolerant bacterial species in the family enterobacteriaceae that most commonly causes foodborne illness, typically enterocolitis or mesenteric lymphadenitis pseudoappendicitis in children. Yersinia pseudotuberculosisis a rare cause of disease in humans. See your doctor, or call healthline on 0800 611 116 for advice if you think you might have yersinia pseudotuberculosis. Along with the more common yersinia enterocolitica, it can cause gastrointestinal infection in various wild and domestic animals. At the final clinical observation, 6 months later, the patient was free of clinical symptoms and had no recurrence of y. Mesenteric caseous lymphadenitis in a cow calf caused by. Corynebacterium pseudotuberculosis is the etiological agent of caseous lymphadenitis cla, a common disease in small ruminant populations throughout the world. The ability to replicate in macrophages is conserved between.
Infection has been reported in equids, sheep, goats, cattle, buffalo, camelids, and rarely humans. Identification of corynebacterium pseudotuberculosis isolates. This is more common in people with weakened immune systems. Yersinia pseudotuberculosis infections in goats and other. Capsular thickening and edema granulomas with central necrosis and microabscesses immunoblasts and plasma cells in cortical and paracortical region, large lymphocytes within sinuses, germinal center hyperplasia. Pseudotuberculosis yersinia pseudotuberculosis infection.
Yersinia pseudotuberculosis causes zoonotic enteric infection in farm animals, wild animals, and birds. Aug 15, 2018 corynebacterium pseudotuberculosis infection is a contagious, zoonotic disease caused by gram positive bacteria corynebacterium pseudotuberculosis old name corynebacterium ovis the infection mostly spreads from domestic grazing animals such as sheep, feral goats, horses, cattle, and even deer. Enteritis caused by yersinia pseudotuberculosis has been reported in australian sheep, most commonly as a. Transfer of the virulence plasmid of yersinia pestis to yersinia. Gross lesions associated with clinical johnes disease in sheep include variable thickening of the distal small intestine, enlargement and edema of the associated lymph nodes, occasional loss of mesenteric fat, and enlarged mesenteric lymphatics in severe cases 5,6,24,26. In rare cases yersinia pseudotuberculosis infection can lead to sepsis infection in the blood. Humans acquire it by ingesting foods or water contaminated by animal feces. Corynebacterium pseudotuberculosis infection and lymphadenitis taloa or mala in the camel. Enteritis caused by yersinia pseudotuberculosis has been reported in australian sheep, most commonly as a cause of diarrhoea in young sheep in winter and spring. One to 3 weeks after the acute phase of the disease, postinfectious complications can occur. Longterm antibiotic treatment and drainage of abscesses is required, but the disease is often chronic, and internal infections have a 30.
The ability to replicate in macrophages is conserved between yersinia pestis and yersinia pseudotuberculosis celine pujol and james b. Yersinia pestis, which causes bubonic plague, is a relatively recent offshoot, perhaps only 1,500 to 20,500 years old, of the less dangerous yersinia pseudotuberculosis, mark achtman of the max planck institute for molecular genetics in berlin and his colleagues report in the nov. In north america, cases have been reported throughout the united states. Paratuberculosis is a contagious, chronic and sometimes fatal infection that primarily affects the small intestine of ruminants. A disease of a wide variety of animal species caused by the bacterium yersinia pseudotuberculosis. Pseudotuberculosis article about pseudotuberculosis by the. Pseudotuberculosis definition is any of several diseases that are marked by the formation of granulomas resembling tubercular nodules and are caused by a bacterium such as yersinia pseudotuberculosis other than the tubercle bacillus. Pseudotuberculous disorders of humans, now seldom called pseudotuberculosis, include actinomycosis, glanders, and nocardiosis q. Specifically, the following virulence factors require an acidic environment at high temperatures to penetrate host cells. Corynebacterium pseudotuberculosis biovar equi is the causative agent of pigeon fever, or dryland distemper in horses. Infections with yersinia pseudotuberculosis serotype iii and y. Overview of paratuberculosis generalized conditions merck. Yersinia enterocolitica and yersinia pseudotuberculosis.
Get a printable copy pdf file of the complete article 646k, or click on a page. Pcr on dna extracted from 96 suspicious isolates, using a pair of corynebacterium pseudotuberculosisspecific. Corynebacterium pseudotuberculosis is a common cause of infection in horses and cattle and leads to chronic abscesses on the limbs and abdomen. Corynebacterium pseudotuberculosis longdom publishing sl. Pseudotuberculosis article about pseudotuberculosis by. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Calves, kids, or lambs should be birthed in areas free of manure, removed from the dam immediately after birth in the case of dairy cattle, bottlefed colostrum that has been pasteurized or obtained from dams that test negative, and then reared segregated as much. Bliska department of molecular genetics and microbiology and center for infectious diseases, state university of new york at stony brook, stony brook, new york 117945222.
It causes caseous lymphadenitis and is involved in deep pyoderma. The possibility of diagnosing the disease in the early stages of infection is one advantage of the proposed method. Oct 11, 2017 yersinia pseudotuberculosis is the least common of the 3 main yersinia species that cause infections in humans. Sequence variability of virulence genes and stress responses in yersinia pseudotuberculosis eveliina palonen academic dissertation to be presented, with the permission of the faculty of veterinary medicine of the university of helsinki, for public examination in walter auditorium of the eebuilding. Caseous lymphadenitis cla of sheep, caused by corynebacterium pseudotuberculosis, has been a significant disease in the majority of sheeprearing regions for over a century.
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